Description
Product Characteristics:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene, binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Subcellular location: Cytoplasm, Nucleus
Synonyms: nucleoside dIPhosphatase kinase B, C myc purine binding transcription factor PUF, NDK B, NDKB, NDP kinase B, NDPKB, NM23 H2, NM23B, Nucleoside diphosphate kinase B, nm23-M2, NME2, Nucleoside diphosphate kinase alpha, p18-12d, puf, MGC107562, MGC107563, MGC111212, non-metastatic cells 2, protein (NM23B)expressed in, NDKB_HUMAN, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2.
Target Information: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]